Quantitative Analysis of Antacid (Aluminum) in Drug by EDX

User Benefits

- The titration method and atomic absorption spectrophotometry require complex sample preparation, but with EDX, analysis is possible with simple sample preparation. - The analysis time is only a few minutes, contributing to work efficiency. - Repeatability is good, and highly accurate results can be obtained.

Introduction

Aluminum (Al) compounds such as aluminum hydroxide gel and synthetic hydrotalcite are widely used as antacids because they have the effect of neutralizing excess stomach acid and reducing irritation of the stomach wall. At pharmaceutical manufacturing sites, the titration method or atomic absorption spectrophotometry is generally adopted for control of antacids in drug products, but these analytical methods have the problems. Because the energy dispersive X-ray fluorescence spectrometer (EDX) enables analysis with only simple sample preparation, and the analysis time is also short, at a few minutes per sample, higher analysis efficiency can be expected. For this reason, EDX has attracted attention as an alternative analytical method to the titration method and atomic absorption spectrophotometry. This article introduces an example of an analysis of an antacid (Al) used in commercially-available drugs.

October 14, 2025 GMT