Multi-omics Analysis Package
LC/MS, GC/MS Data Analysis Software
The Multi-omics Analysis Package is metabolic engineering software that can automatically generate metabolic maps and perform a variety of data analysis based on the vast amounts of mass spectrometry data generated in fields such as metabolomics, proteomics, and flux analysis. In conjunction with the various method packages and databases offered by Shimadzu for metabolomic analysis, the Multi-omics Analysis Package can help increase the efficiency of metabolomic data analysis work. The intuitive visualization of data provides powerful support for drug discovery, functionally-enhanced foods, bioengineering, and other life sciences research applications.
Visualize Changes in Compound Quantities on a Metabolic Map Using Simple Operations
The software dramatically decreases the amount of work required for graphing measurement data or displaying it on a metabolic map.
Identify Significant Compounds Using Simple Operations
It makes it easy to use volcano plots for comparing two groups, principal component analysis (PCA) for comparing multiple groups, hierarchical clustering analysis (HCA), and box plots. Linked PCA, HCA, and box plot results can be displayed in the same window to conveniently identify significant compounds. The metabolic map can be enlarged to confirm where identified compounds are located on the map and to support confirming and interpreting the data.
Includes Visualization Template Files Compatible with a Variety of Method Packages
The templates are designed to work in combination with various Shimadzu method packages. These packages contain sample pretreatment methods and analytical conditions for use as “ready-to-use methods,” which ensure the entire process, from mass spectrometry analysis to data analysis, can be performed with ease. In particular, these visualization templates (metabolic maps) are compatible with method packages for primary metabolites, cell culture profiling, lipid mediators, and bile acid. The templates can be used as-is or customized using simple operations.
The Process Flow of Multi-omics Analysis Package
Tools for Data Analysis
The Multi-omics Analysis Package is based on software tools (called gadgets) that have been released on the GARUDA platform - an open research platform developed by the GARUDA Alliance and led by The Systems Biology Institute, Japan (SBI).
Data Analysis Tools Used in the Multi-omics Analysis Package
Volcano Plot
A tool that combines a t-test (statistically significant difference) and a fold-change (Example: Difference in mean value such as 2 times or 1/2) to visualize the differences between the two groups. The Volcano Plot gadget developed by Shimadzu is included in the package.
EasyStats
This tool is for visualizing principal component analysis (PCA) or hierarchical cluster analysis (HCA) results or box plots (including t-test) of measurement data. It can display metabolite data analysis results in a single window to enable comprehensive determination of characteristic changes.
VANTED
Tool maintained at University of Konstanz, Germany, for visualization and analysis of networks across different data sets. (GARUDA support was developed at Monash University)
Cytoscape
Bioinformatics tool developed by the Cytoscape Consortium, used to visualize metabolic pathways, to integrate gene expression profiles with related data, and so on. It is especially useful for analyzing networks and visualizing correlations.
LC/MS/MS Method Packages Supported by Multi-omics Analysis Package
* The Multi-omics Analysis Package is included with the LC/MS/MS Method Package for Primary Metabolite, Cell Culture Profiling, and Metabolites Method Package Suite.
News / Events
-
Cosmetics and Personal Care Products
The environment surrounding cosmetics and personal care products is changing. In addition to serving the original aesthetic purpose, cosmetics are required to be environmentally friendly and impart no adverse effects on animals.
-
Shimadzu has released the LC/MS/MS Method Package for Reactive Sulfur Profiling.
Sample Pretreatment Protocols and Analytical Methods for 17 Sulfur-Containing Metabolites,Including Reactive Sulfur Species
-
Shimadzu has released the LCMS-9050 Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer.
The LCMS-9050 is a quadrupole Time-of-Flight (Q-TOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models and that results in among the highest mass accuracy stability levels available.
-
Dementia / Alzheimer‘s disease
Shimadzu is a leading driver in developing healthcare solutions with technology developments ranging from advanced imaging systems for use in medical diagnosis and treatment, engineering mass spectrometry-based solutions for exploring ways to discover disease biomarkers as well as building MS solutions for daily routine quantitation in biological fluids.
-
Sports doping
Anti-doping policies, rules and regulations are governed by the World Anti-Doping Agency (WADA). Doping is not only harmful to athletes who take performance-boosting drugs, but also affects the integrity of a sport. Shimadzu instruments can help ensure clean sports and here are a few applications.
-
Shimadzu has released the LCMS-2050 High-Performance Liquid Chromatograph Mass Spectrometer.
The LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS to provide a complete package of easy to use high-level performance and compactness.
Sustainability initiatives
-
3 Good health and well-being