Water soluble vitamins contain many highly polar basic components, which are known to exhibit weak retention in the reverse-phase mode.
Shim-pack MAqC-ODS
HPLC Column
Shim-pack MAqC-ODS I reversed-phase columns are packed with a silica gel containing metal and added octadecylsilyl group. In addition to the hydrophobic characteristics of the ODS, the metal content also provides cation-exchange effects. This increases the retention of basic compounds. Therefore, this allows use with only a buffer solution as the mobile phase for analyses that previously required using an ion pair reagent and enables using gradient elution. These characteristics are especially beneficial for analyzing water soluble vitamins and pharmaceuticals that contain a large amount of basic compounds.
Features
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Many pharmaceuticals are basic compounds. The majority of impurities in pharmaceuticals, such as unreacted ingredients, by-products, and decomposition products... -
News / Events
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Shimadzu has released the Method Scouting System.
Method Scouting System is a method development system based on Shimadzu’s UHPLC technology.
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Shimadzu has released the Nexera MX.
Nexera MX processes twice the number of samples as conventional LCMS systems in the same amount of time.
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“Advanced i-Series” High Performance Liquid Chromatograph
Retaining the excellent basic functions of the flagship “i-Series”, the Advanced i-Series boasts increased pressure resistance and additional functions to support remote work including working from home.
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Shimadzu has released the ELSD-LT III Evaporative Light Scattering Detector for HPLC.
The evaporative light scattering detector (ELSD) is a general-purpose universal detector that can even detect components with no UV absorption, such as carbohydrates, lipids, surfactants, and synthetic polymers.
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Shimadzu has released the Microsampling Device, MSW2™ Type Udck™
For Research Use Only. Not for use in diagnostic procedures.
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Application Note: "Analysis of Pharmaceuticals' Impurity - Regulations and Analysis for Carcinogenic Substances -"