Water soluble vitamins contain many highly polar basic components, which are known to exhibit weak retention in the reverse-phase mode.
Shim-pack MAqC-ODS
HPLC Column
Shim-pack MAqC-ODS I reversed-phase columns are packed with a silica gel containing metal and added octadecylsilyl group. In addition to the hydrophobic characteristics of the ODS, the metal content also provides cation-exchange effects. This increases the retention of basic compounds. Therefore, this allows use with only a buffer solution as the mobile phase for analyses that previously required using an ion pair reagent and enables using gradient elution. These characteristics are especially beneficial for analyzing water soluble vitamins and pharmaceuticals that contain a large amount of basic compounds.
Features
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Many pharmaceuticals are basic compounds. The majority of impurities in pharmaceuticals, such as unreacted ingredients, by-products, and decomposition products... -
News / Events
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Shimadzu has released ELSD-LT III Evaporative Light Scattering Detector for HPLC.
The evaporative light scattering detector (ELSD) is a general-purpose universal detector that can even detect components with no UV absorption, such as carbohydrates, lipids, surfactants, and synthetic polymers.
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Shimadzu has released the Microsampling Device, MSW2™ Type Udck™
For Research Use Only. Not for use in diagnostic procedures.
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Application Note: "Analysis of Pharmaceuticals' Impurity - Regulations and Analysis for Carcinogenic Substances -"
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Shimadzu has released Shim-pack MC PLONAS Series.
Shim-pack MC PLONAS 2.7 μm columns reduce the back pressure yet maintain the performance of a sub 2 μm fully porous particle column. The pressure limit is 40 MPa.
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Application Note: "Various Analysis Techniques for Organic Acids and Examples of Their Application"
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TORAST-H Vial Series
LC/MS(/MS) has been introduced in many fields as an indispensable separation analysis method thanks to its high sensitivity and selectivity.