Water soluble vitamins contain many highly polar basic components, which are known to exhibit weak retention in the reverse-phase mode.
Shim-pack MAqC-ODS
HPLC Column
Shim-pack MAqC-ODS I reversed-phase columns are packed with a silica gel containing metal and added octadecylsilyl group. In addition to the hydrophobic characteristics of the ODS, the metal content also provides cation-exchange effects. This increases the retention of basic compounds. Therefore, this allows use with only a buffer solution as the mobile phase for analyses that previously required using an ion pair reagent and enables using gradient elution. These characteristics are especially beneficial for analyzing water soluble vitamins and pharmaceuticals that contain a large amount of basic compounds.
Features
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Many pharmaceuticals are basic compounds. The majority of impurities in pharmaceuticals, such as unreacted ingredients, by-products, and decomposition products... -
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