All sample processing, from introduction, separation and concentration of target compounds, desalting and solvent replacement, to transfer to the LC-MS, has been completely automated.
Co-Sense for LC-MS
Liquid Chromatograph with online Sample Preparation

In LC-MS, there are various factors which may preclude the applicability of HPLC with MS analysis, including the interference associated with non-volatile buffers often used in HPLC. Therefore, tedious procedures are adopted, in which separation and collection is conducted by HPLC, and after desalting and other processing, MS measurement is performed.
Co-Sense for LC-MS automates the entire process of separating and purifying the target compounds from the sample, including the processes of purifying, concentrating and desalting. This eliminates the need to select HPLC mobile phases to accommodate subsequent measurement using LC-MS.
Features
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Fully Automated Sample Processing
All sample processing, from introduction, separation and concentration of target compounds, desalting and solvent replacement, to transfer to the LC-MS, has been completely automated.
News / Events
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An Improvement in Preparative SFC Efficiency Utilizing Online SFE-SFC System as a “Solid Autosampler”
Preparative SFC is a groundbreaking separation and purification technology. It has a number of advantages in comparison to preparative LC including simplified posttreatment, shorter analysis times, and different separation selectivity. With preparative SFC, the injection of large sample volumes is often required in order to increase the recovered amount.
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SFC Analytical Condition Parameters is available.
The approach for the SFC analytical condition development process is basically the same as for determining analytical conditions for HPLC.
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Latest issue of Shimadzu Journal, featuring Forensics / Toxicology, has come out.
This issue focuses on "Forensics / Toxicology", an area where science and technology are particularly important and needed. It starts with two customer interviews.
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Analysis of Tea Beverages Using Catechin Analysis Kit
The catechin analysis kit, developed in collaboration with the National Agriculture and Food Research Organization (NARO), provides validated test methods for catechins in tea leaves and green tea drinks from sample pre-treatment to HPLC measurement. You can accurately quantitate the content of 11 catechins (including methylated catechins) and caffeine in tea leaves. This article summarizes the results of the catechins quantitation in several beverages: green tea, black tea, and oolong tea.
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Extraction and Fractionation of Functional Ingredients with Online SFE-SFC
This article describes a preparative online supercritical fluid extraction-supercritical fluid chromatography (SFE-SFC) system that combines an extraction step using supercritical carbon dioxide as the solvent, a separation step using supercritical carbon dioxide as the mobile phase, and a fractionation step using a preparative-scale fraction collector (FRC).
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New UF-Amino Station
UF-Amino Station, which was developed in collaboration with Ajinomoto Co., Ltd., uses a special high-speed and high-separation column and the LCMS-2020 mass spectrometer, to perform batch analyses of 38* amino acids and amino acid-related components in a mere 9 minutes.