Liquid Chromatograph with online Sample Preparation
In LC-MS, there are various factors which may preclude the applicability of HPLC with MS analysis, including the interference associated with non-volatile buffers often used in HPLC. Therefore, tedious procedures are adopted, in which separation and collection is conducted by HPLC, and after desalting and other processing, MS measurement is performed.
Co-Sense for LC-MS automates the entire process of separating and purifying the target compounds from the sample, including the processes of purifying, concentrating and desalting. This eliminates the need to select HPLC mobile phases to accommodate subsequent measurement using LC-MS.
Shimadzu has released the Shim-pack™ SUR-Na Columns for Ligand Exchange Chromatography.
Shim-pack™ SUR-Na, a ligand exchange chromatography column, offers excellent performance by combining size exclusion mode and sodium-based ligand exchange mode to provide superior separation of sugar components. Pure water can be used for the mobile phase, resulting in less effort to prepare for the analysis.
Efficient Method Development by automated pH Screening with LabSolutions MD
This article describes an example of using LabSolutions MD, a dedicated software for supporting method development, to automate pH screening by varying the mobile phase pH from 2.5 to 8.5 to evaluate the optimal pH level for separating 12 small-molecule drugs.
Oligonucleotide Therapeutics Solution Guide is now available
Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases (including modified bases) linked together. They are produced by chemical synthesis and act directly on organisms without being translated into proteins.
Cosmetics and Personal Care Products
The environment surrounding cosmetics and personal care products is changing. In addition to serving the original aesthetic purpose, cosmetics are required to be environmentally friendly and impart no adverse effects on animals.
Shimadzu has released the Catechin Analysis Kit
The National Agriculture and Food Research Organization (NARO) and Shimadzu are studying fast, convenient, and accurate methods for analyzing the functional components in foods for purposes of data analysis and social implementation.
Shimadzu has updated the LabSolutions MD
LabSolutions MD uses an “Analytical Quality by Design” (AQbD) approach for achieving efficient method development by designing analysis methods based on science and risk.
