LCMS-8065XE - Características
NUEVOLC-MS/MS de triple cuadrupolo
EVOLVED
Revolutionary New Technology Achieves Exceptional Performance
Our latest technologies included in the LCMS-8065XE bring sample analysis to a new level. Through evolution of our UF technologies, ESI probe, and collision cell, we are pushing the boundaries to achieve the highest level of performance.
Exploring the Core of High-Sensitivity Analysis
The newly designed StreamFocus ESI probe enhances UFsensitivity™ analysis by reducing droplet dispersion within the ESI spray. Equipped with a specially engineered low-diffusion nebulizer nozzle, it enables greater ion intake while reducing nebulizer gas consumption—making it particularly well-suited for reducing operational expenses.
The IonFocus unit in the LCMS-8065XE optimizes ion transmission. It solves the common trade-off between contamination reduction and sensitivity loss by using an electrode to focus and direct only target ions into the mass spectrometer, excluding neutral contaminants. This results in high sensitivity, exceptional robustness, and enhanced instrument uptime for reliable, long-term analysis.
EFFICIENT
New UF Technologies Enable Ultra-Fast Mass Spectrometry Applications
Shimadzu’s triple quadrupole mass spectrometers, powered by a suite of proprietary UF Technologies, have earned widespread acclaim from users across diverse applications. The new LCMS-8065XE incorporates the latest advancements in these technologies, delivering unmatched sensitivity and faster analysis speeds—redefining what’s possible in quantitative mass spectrometry.
UFsweeper™ Ⅳ
Shimadzu's proprietary UFsweeper™ technology—designed to efficiently guide ions through the collision cell without energy loss—has been further refined. The updated collision cell features a larger entrance lens diameter and an increased number of lenses, significantly boosting ion throughput. These improvements result in enhanced ion transmission and greater sensitivity, enabling more precise and reliable quantitative analysis.
El mantenimiento sencillo reduce el tiempo de inactividad del instrumento
Both the desolvation line (DL), which delivers samples to the vacuum section, and the ESI capillary can be replaced quickly and easily. Even the DL can be replaced without breaking vacuum, helping to minimize downtime and maintain laboratory productivity.
Maximización de la eficiencia general del flujo de trabajo
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Herramientas inteligentes para ayudar a que la eficiencia de su flujo de trabajo genere mayor productividad y mejor calidad de los datos.
Preparación
Verificación del instrumento
PERFORMANCE CONCIERGE™ makes tuning a mass spectrometer easier than ever before. Se introduce automáticamente un estándar de ajuste en el instrumento para verificar los parámetros, incluida la precisión de la masa, la resolución y la intensidad de la señal. Con base en estas verificaciones, el ajuste puede iniciarse automáticamente para garantizar un rendimiento óptimo. Si no se cumplen los criterios, el ASISTENTE DE RENDIMIENTO diagnosticará el problema y alertará al operador sobre el mantenimiento requerido y maximizará el tiempo de actividad.
Optimización de las condiciones de adquisición
Automatiza la optimización de MRM para crear métodos cuantitativos de LC-MS/MS de alta sensibilidad. LabSolutions Connect MRM no solo optimiza las transiciones de MRM del componente diana y las energías de colisión, sino que también maximiza la respuesta para el análisis en columna. Todos los parámetros de adquisición optimizados se almacenan en una base de datos, lo que ayuda a acelerar el desarrollo de métodos y el análisis de rutina.
Puesta en marcha
Inteligencia integrada en la serie Nexera LC que le permite aumentar la vida útil de la columna y reducir los consumibles, al permitir el equilibrio automático de la columna para los índices de flujo y la temperatura.
Revisión de datos e informes de resultados
LabSolutions Insight respalda un panorama dinámico de revisión cuantitativa de datos con las herramientas para impulsar una alta confianza en los informes de resultados mediante “revisión por excepción”. Insight se puede configurar para verificar si hay valores atípicos fuera del alcance de los criterios definidos por el usuario para informar resultados.
Análisis de datos
Integración de picos
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This example demonstrates the use of Peakintelligence for integration of LC/MS peaks of per- and polyfluoroalkyl substances (PFAS). It confirms accurate peak integration even for signals with low signal-to-noise (S/N) ratios. Peak intelligence for LCMS also reduces detection errors caused by baseline noise or undulations to achieve more consistent quantitative analysis results. Revolutionary AI-driven peak detection and integration technology delivers consistent, accurate results even for challenging low signal-to-noise peaks. The intelligent algorithm automatically identifies components and integrates peaks without requiring manual parameter adjustment, while effectively suppressing false positives caused by baseline noise and drift.
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PeakIntelligence dramatically reduces time-consuming manual review processes (up to 67%) and delivers superior reproducibility across complex analyses like PFAS quantification. Experience higher confidence in your results with automated processing that maintains accuracy while accelerating your analytical workflow.
EXACT
The chromatogram below illustrates the part-per-trillion analysis of a 1 ng/L mixed standard solution of PFAS (Per- and Polyfluoroalkyl Substances). Despite the extremely low concentration of 1 ng/L, the compounds are detected with good peak intensity. The LCMS-8065XE, equipped with the innovative StreamFocus and UFsweeper IV, delivers exceptional sensitivity for the analysis of trace-level components.
The LCMS-8065XE exhibits exceptional robustness during continuous analysis of complex matrices. The data above show both absolute peak areas relative to the initial response and peak area ratios normalized using internal standards, obtained from over 10,000 consecutive injections of treated wastewater samples. To create a more challenging analytical environment, matrix elimination using LC switching valves was deliberately omitted. Even under these challenging conditions, the system retained over 85% of its initial response after 10,000 injections, highlighting its exceptional durability and stability in demanding high-throughput applications.
Championing Sustainability for a Better Tomorrow
High Energy Efficiency
The LCMS-8065XE includes ecology mode functionality that checks the system usage status and automatically shuts down the system if it has not been used for a certain period of time. Using the ecology mode can reduce electricity consumption by about 31%. It also contributes significantly to reducing power consumption by not using LC-MS/MS peripheral equipment except during analysis. Moreover, reducing CO2 emissions contributes to achieving a carbon-neutral society.
Fast-Tracking Sustainability with Nexera UHPLC and LCMS-8065XE
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Combining the LCMS-8065XE with a Nexera series UHPLC system enables ultra-fast analysis and significantly enhances analytical throughput. This increased efficiency also leads to substantial reductions in solvent, gas, and electricity consumption, resulting in lower operational costs.
- NOTE: Power consumption calculations assume 8 hours of analysis on weekdays and no hours on weekends (with ESI interface switched OFF)
Without Ecology Mode
ESI interface remains ON after analysis.
With Ecology Mode
Ecology mode is activated after analysis (with ESI interface switched OFF).
UFMS, Analytical Intelligence logo, UFsweeper, UFsensitivity, IonFocus, UF-Qarray, UF-Lens, UFscanning, UFswitching, UF-MRM, PERFORMANCE CONCIERGE, LabSolutions Connect, LabSolutions Insight, LabSolutions, Peakintelligence and Nexera are trademarks of Shimadzu Corporation or its af filiated companies in Japan and/or other countries.
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