USP Analysis of Almotriptan Tablets and Related Substances

Introduction

Almotriptan is a triptan drug developed for the treatment of acute migraine. It was reported as one of the best-responding triptans for its efficacy in pain relief and sustained pain-free rate. Almotriptan is a highly selective serotonin 5-HT_1B/1D receptor agonist. It is believed to induce vasoconstriction and inhibition of signal transmission by acting on 5-HT_1B and 5- HT_1D receptor subtype respectively, thereby relieving a migraine attack. USP methods are often used as a basis for routine analysis of generically manufactured drugs. Column used in USP methods differs for each monograph. Here, we demonstrate the analysis of almotriptan tablets and related substances in accordance with the USP monograph on a Nexera^TM X2 system with Shim-pack Velox^TM column. A C18 column with L1 designation was stated in USP monograph of almotriptan tablets. Shim-pack Velox column, a core- shell column was chosen for its efficacy, robustness and reduced backpressure. The Nexera X2 system was used for its reliable and precise performance.

September 13, 2019 GMT