Wide-area, Fast, and High-definition MS Imaging of Mouse Brain Using iMScope QT

User Benefits

�- The maximum measurable area of iMScope QT exceeds 1 mega pixels, allowing for analysis of a large area, such as a whole mouse brain slice in a single run. �- The analysis speed of iMScope QT is more than 8 times faster than that of iMScope TRIO, allowing for a rapid analysis. �- The iMScope QT has high mass accuracy (<1 ppm) and high mass resolution (>30000) to obtain accurate masses.

Introduction

In MS imaging, biomolecules and metabolites are measured directly by a mass spectrometer while maintaining the positional information on the sample tissue in order to produce a two-dimensional distribution map of various biomolecules using the obtained signal intensity of specific ions in the mass spectrum and the positional information. The iMScope mass microscope is the hybrid type of instrument that specializes in this MS imaging, combining an optical microscope and a mass spectrometer, which enables the analysis of structure and distribution of substances, expanding the possibilities of research in all fields including drug discovery and metabolite studies. The iMScope can also be used for LC-MS qualitative and quantitative analysis by switching the MALDI part to an LC and ESI system. In this article, we will introduce the features of the further evolved, new iMScope QT, equipped with a Q- TOF mass spectrometer, while comparing with the previous model, iMScope TRIO.

July 16, 2021 GMT