Breakthrough Sensitivity and Robustness for PFAS Analysis in Chicken Tissue for EPA Method 1633A

User Benefits

- LCMS-8065XE achieved up to 80 times lower limit of quantifications than LLOQ concentration in EPA Method 1633A. - The measurement time was 10 min while meeting the chromatographic requirements by EPA Method 1633A. - This method showed the excellent robustness across 7 days of over 900 continuous injections of the matrix sample.

Introduction

Per- and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic chemicals widely used in industry and consumer products. Owing to their persistence and potential health risks, PFAS have become a major environmental concern. The U.S. Environmental Protection Agency (EPA) has developed standardized analytical methods, including EPA Method 1633A, to monitor PFAS contamination in a wide range of environmental and biological matrices. This study evaluates the performance of LCMS-8065XE for PFAS analysis in accordance with EPA Method 1633A. By assessing calibration stability over the course of one week, we demonstrate the method’s suitability for routine PFAS monitoring. All aspects of the workflow including sample extraction, preparation, and analysis, were performed in compliance with EPA Method 1633A guidelines. Our results highlight the system’s robustness and minimal downtime, underscoring its value for laboratories responsible for delivering rapid and reliable PFAS determinations.

September 2, 2025 GMT