Per- and Polyfluoroalkyl Substances (PFAS)
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Per-and polyfluoroalkyl substances (PFAS) are a group of persistent and harmful chemicals that can be commonly found in the environment globally. These anthropogenic chemicals can come from various sources such as manufacturing, industrial applications, food contact materials and consumer products, and eventually end up and accumulate in the water, soil and living organisms. With concerns rising quickly about the health risks associated with PFAS exposure, it is important to ensure proper monitoring of these chemicals.
| Method | EPA 537 & 537.1 | EPA 533 | EPA 8327 | EPA Draft 1633 | ASTM D8421-22 | ASTM D7968-19 |
| Sample | Drinking Water | Drinking Water | Ground/ Surface/ Wastewater | Aqueous, solid (soil, biosolids, sediment), tissue samples | Aqueous (municipal and industrial wastewater, leachate) | Soil Sediment Sludge |
| Sample Preparation | Solid phase extraction (polymeric sorbent) | Solid phase extraction (anionic sorbent) | Cosolvation + direct injection | Solid phase extraction (anionic sorbent) or solvent extraction + clean-up | Cosolvation + direct injection | Solvent extraction + direct injection Soil Sediment Sludge |
| Quantitation | Internal standard calibration (1 MRM) | Isotopic dilution | External calibration | Isotopic dilution | External calibration (2 MRMs) Isotopic dilution optional | External calibration (2 MRMs + ion ratio) |
| Targets | EPA 537 – 14 EPA 537.1 – 18 |
25 | 24 | 40 | 44 | 21 |
| Applicable LC-MS/MS Platforms | LCMS-8045 LCMS-8050 |
LCMS-8045 LCMS-8050 |
LCMS-8050 LCMS-8060 LCMS-8060NX |
LCMS-8045 LCMS-8050 LCMS-8060 LCMS-8060NX |
LCMS-8050 LCMS-8060 LCMS-8060NX |
LCMS-8050 LCMS-8060 LCMS-8060NX |
New Product
Provides Methods for Analyzing Per- and Polyfluoroalkyl Substances in Drinking Water According to EPA Methods 533 and 537.1
The United States Environmental Protection Agency (US EPA) has standardized two methods for the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in drinking water: EPA Method 537.1 and 533, encompassing a total of 29 PFAS. These methods were used as reference for creating a vetted LC/MS/MS Method Package for Analyzing PFAS in Drinking Water. This method package includes ready-to-use analytical conditions for EPA Methods 533 and 537.1, examples of analytical procedures for the methods, and various other information, such as precautions for sample preparation and analysis. Using this product, 52 PFAS compounds* in drinking water can be analyzed.
Handbook of Analysis Procedures
Related Application
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Provides Methods for Analyzing PFAS in Drinking Water According to EPA Methods 533 and 537.1
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PFAS: Essentials for Analysis by LC-MS/MS
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Solutions for PFAS Analysis
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Analysis of PFAS Compounds in Fish Tissue Using Offline Supercritical Fluid Extraction and LC-MS/MS
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Analysis of PFAS Specified in EPA M537.1 Using the Triple Quadrupole LCMS-8045
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Ultra-fast LC-MS/MS Analysis of PFAS in Environmental Samples
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