Rapid Measurement of Low-molecular Compounds Using a Benchtop MALDI-TOF Mass Spectrometer

Introduction

MALDI-TOF mass spectrometry is generally considered as an effective analysis method for molecules having a high molecular weight such as proteins and peptides. However, this method can also be used for low-molecular compounds as a rapid, simple analysis method. In particular, since the analysis is hardly affected by salts that may be contained in samples, target components in the product can be analyzed directly without any pretreatment such as purification. For example, commercially available oral care products contain bactericidal components (povidone- iodine, chlorhexidine gluconate, etc.), and such low- molecular antiseptic components can be directly detected from the products. This article introduces examples of detecting antiseptic components from commercially available oral care products using a benchtop MALDI-TOF mass spectrometer.

October 11, 2017 GMT