Pharmaceuticals, foods, environmental testing, and many other fields require a wide variety of separation methods, such as for separating chiral compounds and structural isomers. Due to the difference in separation selectivity between ultra high performance liquid chromatography (UHPLC) and supercritical fluid chromatography (SFC) using supercritical carbon dioxide and organic solvents, SFC has been highly anticipated in recent years as a new separation method. By combining both UHPLC and SFC, the Nexera UC/s UHPLC/SFC switching system enables both UHPLC and SFC analysis using a single system. Since SFC has different separation characteristics than UHPLC, it can improve separation between isomers. By using two separation methods, UHPLC and SFC, for screening during the method development process, the system can result in configuring superior analytical conditions more quickly.