Nexera XS inert
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This article introduces the use of the Nexera XS inert ultra-high performance liquid chromatograph, which utilizes a metal-free flow path, and a metal-free column for the accurate and reproducible analysis of nucleotides.
The potential adsorption of an analyte onto wetted surfaces of UHPLC instruments poses some critical challenges when analyzing biomolecules. While elevated pressure tolerance is required to achieve optimal chromatographic separation when using small particle size columns, the inertness of the wetted surfaces is also of the utmost importance, as is resistance to corrosion due to the use of mobile phases with high salt concentrations and extreme pH values.
The Nexera XS inert system offers the ideal solution for the separation of biomolecules by combining the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, ensured by the absence of wetted metal surfaces and offering ultra-high resistance to corrosion.
Unconstrained Recovery and Sensitivity
Reduces sample loss due to adsorption to metal and achieves excellent sensitivity.
Clear Resolution without Restrictions
Improves peak shape and achieves excellent chromatographic separation.
Assured Reliability and Reproducibility
Reliable data for metal-adsorbing compounds with high reproducibility.