Analysis of Modification Site of Chemically Modified Antibody Using MALDImini™-1 Compact MALDI Digital Ion Trap Mass Spectrometer

In evaluations of antibody drug conjugates (ADC), a new class of anti-cancer drugs in which an antibody is bound to a cytotoxic drug, the compound binding site on the protein is one of the critical quality properties.
This article reports an example in which a pseudo ADC was created by artificially binding a low-molecular compound to a standard research antibody, and the chemical modification site was analyzed by using a compact MALDI digital ion trap (DIT) mass spectrometer.