Genome Editing and Creating Mutant Strains in Medaka

In recent years, various genome editing technologies have been developed, such as the TALEN (Transcription Activator-Like Effector Nuclease) and CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein) systems, which allow DSB (Double-Strand Breaks) to be introduced at any desired sequence in the genome. The two are fundamentally different. TALEN is an artificial nuclease of chimeric protein which has a nuclease domain. CRISPR/Cas systems utilize an RNA-guided RGEN (RNA-guided endonuclease).1,2,3) Following those developments, a broad variety of tools based on such technology have been developed, and advancements are being made day by day.

Content Type:
Application
Document Number:
LAAN-C-XX-E020A
Product Type:
Life Science Lab Instruments, Electrophoresis, Chemical Inkjet Printer
Keywords:
Heteroduplex mobility assay (HMA) method, polyacrylamide gel electrophoresis, microchip electrophoresis system, TALEN (Transcription Activator-Like Effector Nuclease) , CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein) systems, RNA-guided RGEN (RNA-guided endonuclease), Pharmaceutical, Life Science, Genomics, Genetics, DNA sequencing, MultiNA
Language:
English
File Name:
jpu216001.pdf
File Size:
2,566kb

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