MUP-3100 - Options

Fully Automated Sample Preparation Module for Glycan Analysis




Glycosylation is one of the most common post-translational modification of proteins. The presence of the glycan moiety and its structural profile must be monitored, since it affects not only the effector function, but also ADME and immunogenicity. Acquiring the glycan structure profile at an early stage of biotherapeutic development helps eliminate any molecules expressing high levels of unfavorable glycan species, e.g. fucosylation. This is taken into account during cell line selection to reduce longterm risk. MALDI-TOF MS methodology offers a simple, high-throughput option for this purpose.

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