LCMS-8060NX - Features

Liquid Chromatograph Mass Spectrometer

The Culmination of Shimadzu's Expertise in Triple Quadrupole Mass Spectrometry

IonFocus™ unit

A newly-developed ESI probe with focus electrodes introduces ions into the mass spectrometer more efficiently, while expelling contaminants to reduce noise and provide more stable data. In addition, an improved heat-assist design promotes the ionization of a wide range of compounds. (Patented technology.)

Simple design without cables or tubes. Remove or replace easily with the "one-touch" lever.

 

 

 

UF-Qarray™Ⅱ, UF-Lens™Ⅱ

Re-engineered ion guide improves robustness without compromising on sensitivity. Maintenance of UF-Qarray II
and UF-Lens II can be performed easily without tools.

 

 

 

Easy maintenance interface

The LCMS-8060NX inherits all the ease-of-maintenance of its predecessors. Both the desolvation line (DL), which introduces the sample into the vacuum, and the ESI capillary can be replaced easily and in a short time. The DL can be replaced while maintaining the vacuum, minimizing downtime.

  • Steps to replace the DL

Steps to replace the DL

  • Steps to replace the ESI capilliary

Steps to replace the ESI capilliary

Robustness and Ease of Use

Maximized sensitivity, minimized matrix effects

In the newly-developed IonFocus unit, the ion transport electrodes reduce sensitivity loss from matrix effects by expelling neutral matrix particles with greater efficiency. The graphs below show an analysis example of residual pesticides in tea leaves. Using the LCMS-8060NX's world-class polarity reversal speed (5 ms) and data capture speed (1.5 ms), stable data was obtained even for high-speed analysis of multiple components. The IonFocus unit also introduces ions into the detector more efficiently, improving the signal intensity. Of the 100 compounds tested, 96% showed excellent recoveries.

 

Superior robustness

The LCMS-8060NX employs new ion guides, the UF-Qarray II and the UF-Lens II, to increase robustness while maintaining high ion transmission efficiency. Improved robustness means higher laboratory throughput as maintenance interval times increase.
The urine metabolite data shown below provides confidence for the analysis of biological matrices. After the analysis of 1000 urine samples, prepared only by dilution with water, the LCMS-8060NX delivers superior data stability without loss of sensitivity.
 

 

New AI-derived parameters optimized for a wide range of compounds

 

The LCMS-8060NX uses new default parameters optimized for a wide range of compounds based on research with AI (Artificial Intelligence) processes, enabling excellent results without the need for labor-intensive investigation of analysis conditions. As shown below, this boosts the signal intensity for a variety of target compounds to an average of 2.6 times the intensity achieved with previous parameters.

 

Efficient desolvation for higher efficiency

A new heat-assisted design improves the desolvation efficiency and dramatically enhances the sensitivity for challenging molecules such as steroid hormones.

Intelligent Automation Improves Workflow Efficiency

 

 

 

 

 

Intelligent start-up with Smart Flow Control

HPLC columns can be damaged by sudden pump starts and stops or extreme gradient changes. The new Nexera automatically uses FlowPilot (Smart Flow Control) to increase the flow rate gradually to the set point. There is no need to create startup protocols for each analysis.

 

Improves data processing throughput

Great time savings can be achieved in multiple component data analysis, with functions to check multiple chromatograms at once, display results that exceed standard values in a different color, etc. In addition, several report format templates are provided, reducing the time needed for report creation.

 

Automatic optimization of MS conditions

Simply set the sample in place and enter the sample information, and MRM and interface parameter optimization will be carried out automatically. The optimization results are shown graphically, reducing the time and effort needed for evaluation.

LC/MS/MS Method Packages and MRM Libraries

Several method packages are available for quick method startup. Analysis can begin right away without MRM optimization or tedious method development.

 

Straightforward pretreatment saves labor

The SIL-40 autosampler series has programmable micro-volume liquid handling capabilities. Apply these sample pretreatment parameters from a simple graphic interface, reducing labor and increasing precision in co-injection, isomerization, etc.

Automatic co-injection with water matches mobile phase conditions, preserving peak shape for early eluters

Software Solutions from Acquisition to Data Review
LabSolutions Connect™ / LabSolutions Insight™

LabSolutions Connect and LabSolutions Insight provide support for the entire analytical workflow, from optimization of MS conditions to data processing, to achieve maximum efficiency.

Project file management made simple
Automatically stay organized with Connect’s file management system. File locations are automatically determined by file type, enabling the technician to carry out analysis or data processing without having to remember file paths. Analyte concentrations and other sample results can be saved as a data processing results file. Multiple processing methods can be used on the same data set, with results stored separately, enabling processing parameter optimization and easy results retrieval.

MRM and ion source optimization
MRM parameters (precursor ion m/z, product ion mz/, voltages) and ion source parameters (gas flow rate, temperature) are automatically optimized. Just one round of comprehensive optimization maximizes sensitivity, taking into consideration polarity, adduct ions, valency etc. The results of this process can be viewed on a graph using the data browser function. The MRM optimization results screen simultaneously displays a chromatogram, a spectrum, and each voltage. From the MRM optimization results screen, check how the signal strength changes with variations in each parameter.

MRM optimization

MRM optimization
Review screen for MRM optimization simultaneously displays precursor ion, product ion, and voltage results.

 
 

Ion source optimization
Review screen for source optimization graphically displays the successive results of each parameter modification.

Simple method creation and batch creation
LabSolutions Connect organizes optimized results in a dedicated database for easy retrieval. Simply select the target compounds from the database to create a method. Existing method files can be read into the database so that all method file information can be managed together. During the creation of sample acquisition batches, the position of vials is shown on the screen so that settings can be applied easily without risk of mistakes. The project management function prevents the user from accidentally overwriting files from a different project.

Batch creation window

Batch creation window
Vial positions and sample types are shown graphically.

 
 
Method creation window

Method creation window
Simply select the compounds to be analyzed and the method is automatically generated.

Efficient data review
LabSolutions Insight is the ideal environment for sample data review. Toggle between sample and compound review modes based on user preference. The multiple chromatogram display accordingly presents all samples for a particular analyte, or all analytes for a particular sample. All chromatograms can simultaneously be zoomed in or out, or docked in a separate monitor to suit analyst needs.
Color-coded flags enable the reviewer to easily spot problem samples for speedy and accurate processing. Flags can be set for a wide variety of QC parameters, not only for values exceeding limits, but also approaching limits. Use standard report templates or file output for universal laboratory information systems integration.

Multi-chromatogram survey display

Multi-chromatogram survey display
Easily carry out peak corrections for multiple chromatograms, and use the flagging function to keep track of samples that need to be checked.

 

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