Impurity intake restricted to 1.5 µg/day max. when taking a drug over a long period (12 months or more)
Example: For a 30 mg daily...
Example: For a 30 mg daily...
Co-Sense for Impurities
Liquid Chromatograph with online Sample Preparation
The FDA draft guidance, "Genotoxic and Carcinogenic Impurities in Drug Substances and Products: Recommended Approaches" prescribes permitted limits for genotoxic impurities in drug substances. These impurities demand more sensitive trace-level analysis than normal impurities. Generally, mass spectrometry methods, such as GC/MS or LC/MS, are used for the high-sensitivity analysis of impurities. However, there is increasing demand for the establishment of a high-sensitivity quantitation method using an absorbance or other conventional detector that is easy to operate and can easily apply existing LC analysis conditions.
Features
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The Co-Sense for Impurities System achieves approximately 10 to 20 times higher sensitivity than 1-D separation only by... -
Using a 1-D and 2-D column with different retention characteristics, or using different mobile phase compositions, permits reliable separation and... -
Significant knowledge and experience are generally required to set the analytical conditions and clean the flow lines of a 2-D separation system. However...
News / Events
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New Anion Suppressor Ion Chromatograph
The HIC-ESP is a new anion suppressor ion chromatograph with built-in electrodialytic suppressor, boasting the same low carryover and excellent injection precision characteristic of Shimadzu HPLCs to bring you highly-reliable results. The newly developed anion suppressor prevents peak spreading and achieves high sensitivity, providing stable functionality even over long periods of use.
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Multiple Analytical Techniques For Carotenoid Analysis In Capsicum Cultivars
Carotenoids and their derivatives are versatile isoprenoids based on a C40 tetraterpenoid skeleton and play a vital role in plants and animals, but, due to their high variability in the chemical structures, isomerization, poor stability and lack of commercially available standards, their identi cation in real samples is a challenging task.
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New Method Development System
LabSolutions™ MD improves method development efficiency by taking an Analytical Quality by Design (AQbD) approach. This software efficiently develops highly reliable analysis methods by configuring mobile phases, columns, and other parameters using an analysis function that automatically generates analysis schedules with the experimental design method and a data analysis function that plots a design space and predicted chromatogram.
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An Improvement in Preparative SFC Efficiency Utilizing Online SFE-SFC System as a “Solid Autosampler”
Preparative SFC is a groundbreaking separation and purification technology. It has a number of advantages in comparison to preparative LC including simplified posttreatment, shorter analysis times, and different separation selectivity. With preparative SFC, the injection of large sample volumes is often required in order to increase the recovered amount.
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SFC Analytical Condition Parameters is available.
The approach for the SFC analytical condition development process is basically the same as for determining analytical conditions for HPLC.
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Latest issue of Shimadzu Journal, featuring Forensics / Toxicology, has come out.
This issue focuses on "Forensics / Toxicology", an area where science and technology are particularly important and needed. It starts with two customer interviews.