The Koichi Tanaka Mass Spectrometry Research Laboratory addresses the ultra-early discovery of illnesses, as well as developing methods of analyzing the molecular structure of substances related to disease and health, based on the MALDI-MS (matrix-assisted laser desorption/ionization mass spectrometry) method.
This video summarizes the laboratory’s history, research themes, and accomplishments in recent years, all in about 4 minutes!
The following list shows the papers introduced in the video and related articles on our website.
1. Liquid Matrix
Yuko Fukuyama, Shuuichi Nakaya, Yuzo Yamazaki, Koichi Tanaka
"Ionic Liquid Matrixes Optimized for MALDI-MS of Sulfated/Sialylated/Neutral Oligosaccharides and Glycopeptides"
Anal. Chem. 2008, 80 (6) pp 2171-2179
DOI: 10.1021/ac7021986
Yuko Fukuyama, Natsumi Funakoshi, Kohei Takeyama, Yusaku Hioki, Takashi Nishikaze, Kaoru Kaneshiro, Shin-ichirou Kawabata, Shinichi Iwamoto, Koichi Tanaka
"3-Aminoquinoline/p-Coumaric Acid as a MALDI Matrix for Glycopeptides, Carbohydrates, and Phosphopeptides"
Anal. Chem. 2014, 86 (4) pp 1937-1942
DOI: 10.1021/ac4037087
2. Amyloid MS
Naoki Kaneko, Akinori Nakamura, Yukihiko Washimi, Takashi Kato, Takashi Sakurai, Yutaka Arahata, Masahiko Bundo, Akinori Takeda, Shumpei Niida, Kengo Ito, Kenji Toba, Koichi Tanaka, Katsuhiko Yanagisawa
"Novel plasma biomarker surrogating cerebral amyloid deposition"
Proc. Jpn. Acad., Ser. B 2014, 90, pp 353–364
DOI: 10.2183/pjab.90.353
Amyloid MS - Analytical Methods for Early Detection of Alzheimer’s Disease from Blood Tests -
Less than a teaspoon of blood can predict Alzheimer’s disease risk. (Press release)
3. SALSA Method
Takashi Nishikaze, Hiroki Tsumoto, Sadanori Sekiya, Shinichi Iwamoto, Yuri Miura, Koichi Tanaka
"Differentiation of Sialyl Linkage Isomers by One-Pot Sialic Acid Derivatization for Mass Spectrometry-Based Glycan Profiling"
Anal. Chem. 2017, 89 (4) pp 2353–2360
DOI: 10.1021/acs.analchem.6b04150
Hisatoshi Hanamatsu, Takashi Nishikaze, Nobuaki Miura, Jinhua Piao, Kazue Okada, Sadanori Sekiya, Shinichi Iwamoto, Naoya Sakamoto, Koichi Tanaka, Jun-ichi Furukawa
"Sialic Acid Linkage Specific Derivatization of Glycosphingolipid Glycans by Ring-Opening Aminolysis of Lactones"
Anal. Chem., 2018, 90(22), pp 13193-13199
DOI: 10.1021/acs.analchem.8b02775
4. Compact MALDI-MSn Instrument
Shinichi Iwamoto, Kosuke Hosoi, Masaji Furuta, Hideharu Shichi, Shosei Yamauchi, Takashi Nishikaze, Shuichi Nakaya, Kiyoshi Watanabe, Kei Kodera, Koichi Tanaka
"Development of MALDImini-1 Digital Ion Trap Mass Spectrometer"
SHIMADZU REVIEW, 2020, 77, No1・2
5. Novel Mass Spectrometry Method
Hidenori Takahashi, Sadanori Sekiya, Takashi Nishikaze, Kei Kodera, Shinichi Iwamoto, Motoi Wada, Koichi Tanaka
"Hydrogen Attachment/Abstraction Dissociation (HAD) of Gas-Phase Peptide Ions for Tandem Mass Spectrometry"
Anal. Chem. 2016, 88 (7) pp 3810-3816
DOI: 10.1021/acs.analchem.5b04888