Analysis of Unstable Compounds Using Online SFE-SFC

Introduction

Supercritical fluids have characteristics of both gas and liquid; low viscosity, high diffusivity and solubility. In particular, carbon dioxide becomes a supercritical fluid at a relatively modest critical point (31.1 °C and 7.38 MPa). Due to its low toxicity, inertness, easy availability, and low cost, supercritical carbon dioxide fluid is used in a wide variety of fields. Analytical applications using it include supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC). Previously SFE and SFC were offline operations for pretreatment or analysis, respectively, and treated as completely separate workflows. However, now SFE and SFC can be connected online using the Nexera UC system, which allows integration of all the processes from pretreatment to data acquisition into a single workflow. This article describes using the Nexera UC system for online SFE-SFC analysis.

October 29, 2015 GMT