Nexera series - Specs

Ultra High Performance Liquid Chromatograph

Nexera X3

Pressure

130MPa

Approx. particle size (*)

sub2 μm-3μm

I.D. (*)

1-3mm

Dual pump

Multi-rinse

Installed as standard

Key features

Shimadzu’s flagship UHPLC model. This high-pressure gradient model minimizes gradient delay volume and is ideal for very high sample numbers or as the front end of an LC/MS system. It is also compatible with low-pressure gradients and mobile phase blending.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

Read more
Show Less

Shimadzu’s flagship UHPLC model. This high-pressure gradient model minimizes gradient delay volume and is ideal for very high sample numbers or as the front end of an LC/MS system. It is also compatible with low-pressure gradients and mobile phase blending.

 Nexera X3 High Pressure Gradient 
  Model Name Features
System controller SCL-40 Color screen with touch panel and system controller with reservoir tray
Number of connectable units : 8 (Using option: 12)
Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump LC-40B X3
Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke)
Allowable maximum pressure : 130 MPa
Flow rate settings range : 0.0001 – 3.0000 mL/min (1.0 – 130 MPa), 3.0001 – 5.0000 mL/min (1.0 – 80 MPa), 5.0001 – 10.0000 mL/min (1.0 – 22 MPa)
Flow rate accuracy :  ≦± 1% (under specified conditions)
Gradient mode : High-pressure gradient (2 solvents (LC-40B X3 standard) or 3 solvents) Quaternary low-pressure gradient (Only available for LC-40D X3)
Gradient Mixer
Autosampler SIL-40C X3
Injection method : Total-volume Injection (standard), loop injection (optional)
Allowable maximum pressure : 130 MPa
Injection volume : 0.1 to 50 μL, 0.1 to 2000 μL (optional)
Injection volume accuracy :  ≦± 1% (5 μL injection, n = 20)
Injection cycle time :  ≦6.7 seconds (under specified conditions)
Column Oven CTO-40S Temperature control type : Forced air circulation
Cooling Method : Electronic cooling
Temperature control range : Room temperature − 10°C to 85°C
Temperature accuracy : ± 0.8°C
Temperature precision : ± 0.1°C
UV-VIS Detector SPD-M30A
Light source : Deuterium (D2) lamp
Number of diode elements : 1024
Wavelength range : 190 to 700 nm
Wavelength accuracy :  ≦± 1 nm
Wavelength reproducibility :  ≦± 0.1 nm
Mobile phase monitor
Software Labsolutions LC/GC Multi LC-PDA


 

Nexera XS

Pressure

105MPa

Approx. particle size (*)

sub 2μm-3μm

I.D. (*)

1-3mm

Dual pump

-

Multi-rinse

Optional

Key features

A highly flexible UHPLC model compatible with both high and low gradients. Not only does this model significantly reduce analysis time, but the use of plate-changers enables efficient analysis of a large number of samples.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

Read more
Show Less

A highly flexible UHPLC model compatible with both high and low gradients. Not only does this model significantly reduce analysis time, but the use of plate-changers enables efficient analysis of a large number of samples.

 Nexera XS Low Pressure Gradient 
  Model Name Features
System controller SCL-40 Color screen with touch panel and system controller with reservoir tray
Number of connectable units : 8 (Using option: 12)
Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump LC-40D XS
Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke)
Allowable maximum pressure : 105 MPa
Flow rate settings range : 0.0001 – 3.0000 mL/min (1.0 – 105 MPa) 3.0001 – 5.0000 mL/min (1.0 – 80 MPa) 5.0001 – 10.0000 mL/min
(1.0 – 22 MPa)
Flow rate accuracy :≦± 1% (under specified conditions)
Gradient mode : High-pressure gradient (2 or 3 solvents) Quaternary low-pressure gradient
Gradient Mixer
Degassing Unit DGU-405 Number of degassed solvents : 5
Degassed ow line capacity : 400 μL/1 line
Operating temperature range : 4 - 35°C
Autosampler SIL-40C XS
Injection method : Total-volume Injection (standard), loop injection (optional)
Allowable maximum pressure : 105 MPa
Injection volume : 0.1 - 50 μL, 0.1 - 2000 μL (optional)
Injection volume accuracy : ≦± 1% (5 μL injection, n = 20)
Injection cycle time : ≦6.7 seconds (under specified conditions)
Column Oven CTO-40S Temperature control type : Forced air circulation
Cooling Method : Electronic cooling
Temperature control range : Room temperature − 10°C - 85°C
Temperature accuracy : ± 0.8°C
Temperature precision : ± 0.1°C
UV-VIS Detector SPD-M30A Light source : Deuterium (D2) lamp
Number of diode elements : 1024
Wavelength range : 190 to 700 nm
Wavelength accuracy : ≦± 1 nm
Wavelength reproducibility : ≦± 0.1 nm
Mobile phase monitor
Software Labsolutions LC/GC Multi LC-PDA


 

Nexera XR

Pressure

70MPa

Approx. particle size (*)

2μm-3μm

I.D. (*)

2-4.6mm

Dual pump

Multi-rinse

Optional

Key features

This UHPLC-like model is the new standard for the Shimadzu LC series. It is compatible with a wide range of analysis conditions from conventional HPLC analysis to ultra-high separation analysis using core-shell columns with a particle size of 3 μm and below.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

Read more
Show Less

This UHPLC-like model is the new standard for the Shimadzu LC series. It is compatible with a wide range of analysis conditions from conventional HPLC analysis to ultra-high separation analysis using core-shell columns with a particle size of 3 μm and below.

 Nexera XR High Pressure Gradient 
  Model Name Features
System controller SCL-40 Color screen with touch panel and system controller with reservoir tray
Number of connectable units : 8 (Using option: 12)
Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump LC-40B XR
Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke)
Allowable maximum pressure : 70 MPa
Flow rate settings range : 0.0001 – 3.0000 mL/min (1.0 – 70 MPa)
3.0001 – 5.0000 mL/min (1.0 – 44 MPa) 5.0001 – 10.0000 mL/min
(1.0 – 22 MPa)
Flow rate accuracy :  ≦± 1% or ± 2 μL/min, whichever greater
(under specified conditions)
Gradient mode : High-pressure gradient (2 solvents (LC-40B XR standard) or 3 solvents) Quaternary low-pressure gradient (Only available for LC-40D XR)
Gradient Mixer
Degassing Unit DGU-403 Number of degassed solvents : 3
Degassed flow line capacity : 400 μL/1 line
Operating temperature range : 4 to 35°C
Autosampler SIL-40C XR
Injection method : Total-volume Injection (standard), loop injection (optional)
Allowable maximum pressure : 80 MPa
Injection volume : 0.1 to 50 μL, 0.1 to 2000 μL (optional)
Injection volume accuracy :  ≦± 1% (5 μL injection, n = 20)
Injection cycle time :  ≦6.7 seconds (under specified conditions)
Column Oven CTO-40S Temperature control type : Forced air circulation
Cooling Method : Electronic cooling
Temperature control range : Room temperature − 10°C to 85°C
Temperature accuracy : ± 0.8°C
Temperature precision : ± 0.1°C
UV-VIS Detector SPD-M40 Light source :Deuterium (D2) lamp, Tungsten lamp
Number of diode elements : 1024
Wavelength range : 190 to 800 nm
Wavelength accuracy :  ≦± 1 nm
Wavelength reproducibility :  ≦± 0.1 nm
Mobile phase monitor
Software Labsolutions LC/GC Multi LC-PDA


 

Nexera lite

Pressure

44MPa

Approx. particle size (*)

above 3μm

I.D. (*)

3mm-

Dual pump

-

Multi-rinse

Optional

Key features

A conventional HPLC model with excellent basic functions and many options for expansion. Cutting-edge AI functions increase the reliability of established analysis workflows. It can be adapted for all application systems.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

Read more
Show Less

A conventional HPLC model with excellent basic functions and many options for expansion. Cutting-edge AI functions increase the reliability of established analysis workflows. It can be adapted for all application systems.

 Nexera lite High Pressure Gradient 
  Model Name Features
System controller SCL-40 Color screen with touch panel and system controller with reservoir tray
Number of connectable units : 8 (Using option: 12)
Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump LC-40D (2pcs)
Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke)
Allowable maximum pressure : 44 MPa
Flow rate settings range : 0.0001 – 5.0000 mL/min (1.0 – 44 MPa)
5.0001 – 10.0000 mL/min (1.0 – 22 MPa)
Flow rate accuracy :  ≦± 1% or ± 2 μL/min, whichever greater
(under specified conditions)
Gradient mode : High-pressure gradient (2 or 3 solvents) Quaternary low-pressure gradient
Gradient Mixer
Degassing Unit DGU-403 Number of degassed solvents : 3
Degassed flow line capacity : 400 μL/1 line
Operating temperature range : 4 to 35°C
Autosampler SIL-40C
Injection method : Total-volume Injection (standard), loop injection (optional)
Allowable maximum pressure : 44 MPa
Injection volume : 0.1 to 100 μL, 0.1 to 2000 μL (optional)
Injection volume accuracy :  ≦± 1% (5 μL injection, n = 20)
Injection cycle time :  ≦6.7 seconds (under specied conditions)
Column Oven CTO-40C Temperature control type : Forced air circulation
Cooling Method : Electronic cooling
Temperature control range : Room temperature − 10°C to 100°C
Temperature accuracy : ± 0.5°C
Temperature precision : ± 0.05°C
UV-VIS Detector SPD-M40 Light source : Deuterium (D2) lamp
Number of diode elements : 1024
Wavelength range : 190 to 700 nm
Wavelength accuracy : ≦± 1 nm
Wavelength reproducibility :  ≦± 0.1 nm
Mobile phase monitor
Software Labsolutions LC/GC Multi LC-PDA


 
 Nexera lite Low Pressure Gradient 
  Model Name Features
System controller CBM-40 Monitor : LabSolutions Web monitor
Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Number of connectable units : 8 (Using option: 12)
Solvent Delivery Pump LC-40D
Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke)
Allowable maximum pressure : 44 MPa
Flow rate settings range : 0.0001 – 5.0000 mL/min (1.0 – 44 MPa)
5.0001 – 10.0000 mL/min (1.0 – 22 MPa)
Flow rate accuracy :  ≦± 1% or ± 2 μL/min, whichever greater(under specified conditions)
Gradient mode : High-pressure gradient (2 or 3 solvents Quaternary low-pressure gradient
Gradient Mixer
Degassing Unit DGU-405 Number of degassed solvents : 5
Degassed flow line capacity : 400 μL/1 line
Operating temperature range : 4 - 35°C
Autosampler SIL-40C
Injection method : Total-volume Injection (standard), loop injection (optional)
Allowable maximum pressure : 44 MPa
Injection volume : 0.1 to 100 μL, 0.1 - 2000 μL (optional)
Injection volume accuracy : ≦± 1% (5 μL injection, n = 20)
Injection cycle time : ≦6.7 seconds (under specified conditions)
Column Oven CTO-40S Temperature control type : Forced air circulation
Cooling Method : Electronic cooling
Temperature control range : Room temperature ― 10°C - 85°C
Temperature accuracy : ± 0.8°C
Temperature precision : ± 0.1°C
UV-VIS Detector SPD-M40 Light source :Deuterium (D2) lamp, Tungsten lamp
Number of diode elements : 1024
Wavelength range : 190 - 800 nm
Wavelength accuracy :  ≦± 1 nm
Wavelength reproducibility :  ≦± 0.1 nm
Mobile phase monitor
Software Labsolutions LC/GC Multi LC-PDA


 

Spec Sheet Downloads

Download the latest spec sheet.

Downloads

Download the latest brochure.