Nexera series - Specs : SHIMADZU (Shimadzu Corporation)

Nexera X3

Pressure	130MPa
Approx. particle size (*)	sub2 μm-3μm
I.D. (*)	1-3mm
Dual pump	✔
Multi-rinse	Installed as standard
Key features	Shimadzu’s flagship UHPLC model. This high-pressure gradient model minimizes gradient delay volume and is ideal for very high sample numbers or as the front end of an LC/MS system. It is also compatible with low-pressure gradients and mobile phase blending.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

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Shimadzu’s flagship UHPLC model. This high-pressure gradient model minimizes gradient delay volume and is ideal for very high sample numbers or as the front end of an LC/MS system. It is also compatible with low-pressure gradients and mobile phase blending.

Nexera X3 High Pressure Gradient　

	Model Name	Features
System controller	SCL-40	Color screen with touch panel and system controller with reservoir tray Number of connectable units : 8 (Using option: 12) Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump	LC-40B X3	Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke) Allowable maximum pressure : 130 MPa Flow rate settings range : 0.0001 – 3.0000 mL/min (1.0 – 130 MPa), 3.0001 – 5.0000 mL/min (1.0 – 80 MPa), 5.0001 – 10.0000 mL/min (1.0 – 22 MPa) Flow rate accuracy : ≦± 1% (under specified conditions) Gradient mode : High-pressure gradient (2 solvents (LC-40B X3 standard) or 3 solvents) Quaternary low-pressure gradient (Only available for LC-40D X3)
Gradient Mixer
Autosampler	SIL-40C X3	Injection method : Total-volume Injection (standard), loop injection (optional) Allowable maximum pressure : 130 MPa Injection volume : 0.1 to 50 μL, 0.1 to 2000 μL (optional) Injection volume accuracy : ≦± 1% (5 μL injection, n = 20) Injection cycle time : ≦6.7 seconds (under specified conditions)
Column Oven	CTO-40S	Temperature control type : Forced air circulation Cooling Method : Electronic cooling Temperature control range : Room temperature − 10°C to 85°C Temperature accuracy : ± 0.8°C Temperature precision : ± 0.1°C
UV-VIS Detector	SPD-M30A	Light source : Deuterium (D₂) lamp Number of diode elements : 1024 Wavelength range : 190 to 700 nm Wavelength accuracy : ≦± 1 nm Wavelength reproducibility : ≦± 0.1 nm
Mobile phase monitor
Software	Labsolutions LC/GC Multi LC-PDA

Nexera XS

Pressure	105MPa
Approx. particle size (*)	sub 2μm-3μm
I.D. (*)	1-3mm
Dual pump	-
Multi-rinse	Optional
Key features	A highly flexible UHPLC model compatible with both high and low gradients. Not only does this model significantly reduce analysis time, but the use of plate-changers enables efficient analysis of a large number of samples.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

Show Less

A highly flexible UHPLC model compatible with both high and low gradients. Not only does this model significantly reduce analysis time, but the use of plate-changers enables efficient analysis of a large number of samples.

Nexera XS Low Pressure Gradient　

	Model Name	Features
System controller	SCL-40	Color screen with touch panel and system controller with reservoir tray Number of connectable units : 8 (Using option: 12) Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump	LC-40D XS	Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke) Allowable maximum pressure : 105 MPa Flow rate settings range : 0.0001 – 3.0000 mL/min (1.0 – 105 MPa) 3.0001 – 5.0000 mL/min (1.0 – 80 MPa) 5.0001 – 10.0000 mL/min (1.0 – 22 MPa) Flow rate accuracy :≦± 1% (under specified conditions) Gradient mode : High-pressure gradient (2 or 3 solvents) Quaternary low-pressure gradient
Gradient Mixer
Degassing Unit	DGU-405	Number of degassed solvents : 5 Degassed flow line capacity : 400 μL/1 line Operating temperature range : 4 - 35°C
Autosampler	SIL-40C XS	Injection method : Total-volume Injection (standard), loop injection (optional) Allowable maximum pressure : 105 MPa Injection volume : 0.1 - 50 μL, 0.1 - 2000 μL (optional) Injection volume accuracy : ≦± 1% (5 μL injection, n = 20) Injection cycle time : ≦6.7 seconds (under specified conditions)
Column Oven	CTO-40S	Temperature control type : Forced air circulation Cooling Method : Electronic cooling Temperature control range : Room temperature − 10°C - 85°C Temperature accuracy : ± 0.8°C Temperature precision : ± 0.1°C
UV-VIS Detector	SPD-M30A	Light source : Deuterium (D2) lamp Number of diode elements : 1024 Wavelength range : 190 to 700 nm Wavelength accuracy : ≦± 1 nm Wavelength reproducibility : ≦± 0.1 nm
Mobile phase monitor
Software	Labsolutions LC/GC Multi LC-PDA

Nexera XR

Pressure	70MPa
Approx. particle size (*)	2μm-3μm
I.D. (*)	2-4.6mm
Dual pump	✔
Multi-rinse	Optional
Key features	This UHPLC-like model is the new standard for the Shimadzu LC series. It is compatible with a wide range of analysis conditions from conventional HPLC analysis to ultra-high separation analysis using core-shell columns with a particle size of 3 μm and below.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

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This UHPLC-like model is the new standard for the Shimadzu LC series. It is compatible with a wide range of analysis conditions from conventional HPLC analysis to ultra-high separation analysis using core-shell columns with a particle size of 3 μm and below.

Nexera XR High Pressure Gradient　

	Model Name	Features
System controller	SCL-40	Color screen with touch panel and system controller with reservoir tray Number of connectable units : 8 (Using option: 12) Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump	LC-40B XR	Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke) Allowable maximum pressure : 70 MPa Flow rate settings range : 0.0001 – 3.0000 mL/min (1.0 – 70 MPa) 3.0001 – 5.0000 mL/min (1.0 – 44 MPa) 5.0001 – 10.0000 mL/min (1.0 – 22 MPa) Flow rate accuracy : ≦± 1% or ± 2 μL/min, whichever greater (under specified conditions) Gradient mode : High-pressure gradient (2 solvents (LC-40B XR standard) or 3 solvents) Quaternary low-pressure gradient (Only available for LC-40D XR)
Gradient Mixer
Degassing Unit	DGU-403	Number of degassed solvents : 3 Degassed flow line capacity : 400 μL/1 line Operating temperature range : 4 to 35°C
Autosampler	SIL-40C XR	Injection method : Total-volume Injection (standard), loop injection (optional) Allowable maximum pressure : 80 MPa Injection volume : 0.1 to 50 μL, 0.1 to 2000 μL (optional) Injection volume accuracy : ≦± 1% (5 μL injection, n = 20) Injection cycle time : ≦6.7 seconds (under specified conditions)
Column Oven	CTO-40S	Temperature control type : Forced air circulation Cooling Method : Electronic cooling Temperature control range : Room temperature − 10°C to 85°C Temperature accuracy : ± 0.8°C Temperature precision : ± 0.1°C
UV-VIS Detector	SPD-M40	Light source :Deuterium (D2) lamp, Tungsten lamp Number of diode elements : 1024 Wavelength range : 190 to 800 nm Wavelength accuracy : ≦± 1 nm Wavelength reproducibility : ≦± 0.1 nm
Mobile phase monitor
Software	Labsolutions LC/GC Multi LC-PDA

Nexera lite

Pressure	44MPa
Approx. particle size (*)	above 3μm
I.D. (*)	3mm-
Dual pump	-
Multi-rinse	Optional
Key features	A conventional HPLC model with excellent basic functions and many options for expansion. Cutting-edge AI functions increase the reliability of established analysis workflows. It can be adapted for all application systems.

*To achieve maximum functionality of both instruments and columns, we recommend using columns with the particle size and dimensions suggested. However, as long as the maximum pressure of the instrument and columns are not exceeded, other columns can be used.
Piping adjustments may be necessary depending on the analysis conditions. Please contact a Shimadzu sales representative for details.

Show Less

A conventional HPLC model with excellent basic functions and many options for expansion. Cutting-edge AI functions increase the reliability of established analysis workflows. It can be adapted for all application systems.

Nexera lite High Pressure Gradient　

	Model Name	Features
System controller	SCL-40	Color screen with touch panel and system controller with reservoir tray Number of connectable units : 8 (Using option: 12) Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc.
Solvent Delivery Pump	LC-40D (2pcs)	Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke) Allowable maximum pressure : 44 MPa Flow rate settings range : 0.0001 – 5.0000 mL/min　(1.0 – 44 MPa) 5.0001 – 10.0000 mL/min　(1.0 – 22 MPa) Flow rate accuracy : ≦± 1% or ± 2 μL/min, whichever greater (under specified conditions) Gradient mode : High-pressure gradient　(2 or 3 solvents) Quaternary low-pressure gradient
Gradient Mixer
Degassing Unit	DGU-403	Number of degassed solvents : 3 Degassed flow line capacity : 400 μL/1 line Operating temperature range : 4 to 35°C
Autosampler	SIL-40C	Injection method : Total-volume Injection (standard), loop injection (optional) Allowable maximum pressure : 44 MPa Injection volume : 0.1 to 100 μL, 0.1 to 2000 μL (optional) Injection volume accuracy : ≦± 1% (5 μL injection, n = 20) Injection cycle time : ≦6.7 seconds (under specied conditions)
Column Oven	CTO-40C	Temperature control type : Forced air circulation Cooling Method : Electronic cooling Temperature control range : Room temperature − 10°C to 100°C Temperature accuracy : ± 0.5°C Temperature precision : ± 0.05°C
UV-VIS Detector	SPD-M40	Light source : Deuterium (D2) lamp Number of diode elements : 1024 Wavelength range : 190 to 700 nm Wavelength accuracy : ≦± 1 nm Wavelength reproducibility : ≦± 0.1 nm
Mobile phase monitor
Software	Labsolutions LC/GC Multi LC-PDA

Nexera lite Low Pressure Gradient　

	Model Name	Features
System controller	CBM-40	Monitor : LabSolutions Web monitor Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc. Number of connectable units : 8 (Using option: 12)
Solvent Delivery Pump	LC-40D	Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke) Allowable maximum pressure : 44 MPa Flow rate settings range : 0.0001 – 5.0000 mL/min (1.0 – 44 MPa) 5.0001 – 10.0000 mL/min (1.0 – 22 MPa) Flow rate accuracy : ≦± 1% or ± 2 μL/min, whichever greater(under specified conditions) Gradient mode : High-pressure gradient　(2 or 3 solvents Quaternary low-pressure gradient
Gradient Mixer
Degassing Unit	DGU-405	Number of degassed solvents : 5 Degassed flow line capacity : 400 μL/1 line Operating temperature range : 4 - 35°C
Autosampler	SIL-40C	Injection method : Total-volume Injection (standard), loop injection (optional) Allowable maximum pressure : 44 MPa Injection volume : 0.1 to 100 μL, 0.1 - 2000 μL (optional) Injection volume accuracy : ≦± 1% (5 μL injection, n = 20) Injection cycle time : ≦6.7 seconds (under specified conditions)
Column Oven	CTO-40S	Temperature control type : Forced air circulation Cooling Method : Electronic cooling Temperature control range : Room temperature ― 10°C - 85°C Temperature accuracy : ± 0.8°C Temperature precision : ± 0.1°C
UV-VIS Detector	SPD-M40	Light source :Deuterium (D₂) lamp, Tungsten lamp Number of diode elements : 1024 Wavelength range : 190 - 800 nm Wavelength accuracy : ≦± 1 nm Wavelength reproducibility : ≦± 0.1 nm
Mobile phase monitor
Software	Labsolutions LC/GC Multi LC-PDA