Nexera Series Ultra High Performance Liquid Chromatograph - Applications

An appropriate start-up procedure, a warm-up of the LC system and a specific System Suitability Test (SST) are critical steps before any analytical LC session in order to ensure high data quality in terms of reproducibility, accuracy, etc., and to reduce maintenance costs (e.g. by prolonging the lifetime of analytical columns). These procedures are often time-consuming for operators, and, if not performed properly, can lead to the loss of data and the waste of time and resources due to the need for re-analysis. In this report, we explain the ways in which we have improved and completely automated system startup and SST through a combination of different technologies

In order to improve productivity in modern analysis laboratories, it is essential to reduce analysis time and maximize throughput through regular maintenance. One issue to be resolved is the interruption of analysis due to unforeseeable problems. An example of this is air bubbles in the flow line, which can cause shifts in retention times, pulsating baselines, unexpected changes in peak shapes. In this report, we describe the effectiveness of auto-diagnostics and auto-recovery functions in detecting and resolving this problem automatically. These functions minimize system downtime due to air bubbles and contribute to the optimization of laboratory productivity.