Untargeted Metabolomics Analysis of Ethanol Exposure in Liver Using LC/QTOF

User Benefits

- Untargeted metabolomics workflow for High-Resolution LC/QTOF (applicable to LCMS-9030 and 9050). - Applying an LC/QTOF method with fast scanning MS/MS to an untargeted metabolomics workflow to identify metabolic profiles in biological tissue samples. - The workflow delivers an end-to-end solution for untargeted metabolomics research requiring minimal prior experience.

Introduction

Ethanol is a psychoactive and toxic substance that can cause dependence and is associated with neuropsychiatric disorders, cancers, cardiovascular disease, pancreatitis, and alcoholic liver disease. The underlying pathology of alcohol-induced diseases, particularly liver disease, involves a complex interplay of factors including alcohol metabolism, inflammation and oxidative stress, ultimately leading to liver damage, fibrosis, and cirrhosis. In this paper, a method developed for the untargeted metabolomics analysis of biological tissues and biofluids was applied to study the metabolic effects of ethanol exposure in the liver using a mouse model.

July 21, 2026 GMT