LabSolutions Insight Profiler Streamlines Analysis of Untargeted Metabolomics Data from LC/QTOF Analysis

User Benefits

- Application of LabSolutions Insight Profiler, a novel software solution for untargeted analysis, bringing together feature detection and alignment, statistical analysis, filtering and compound identification into a single processing method. - The workflow has been applied in a study to reveal potential candidate biomarkers of pancreatic cancer. - LabSolutions Insight Profiler delivers an end-to-end solution for untargeted metabolomics research automating complex data processing from sample analysis through to identification of statistically significant features.

Introduction

Advances in untargeted metabolomics increasingly rely on integrated workflows which utilise complex spectral deconvolution, data alignment, and multivariate interpretation. Several applications provide complementary capabilities for data processing and statistical analysis; however, transitioning data across discrete platforms increases workflow fragmentation, especially for large scale metabolomics studies. In this application, a single software package, LabSolutions Insight Profiler, has been developed to automate feature detection and alignment, statistical analysis and filtering with compound identification, delivering an integrated workflow solution for untargeted analysis applications such as metabolomics. The data processing application has been applied to a biomarker discovery study with pancreatic cancer serum samples from patients with pancreatic ductal adenocarcinoma (PDAC) and healthy controls analysed by LC/QTOF on the LCMS-9030. The workflow is applicable to any untargeted metabolomics study using the LCMS-9030 or LCMS-9050 QTOF. The research project was approved by the Pancreatic Cancer Research Fund Tissue Bank (PCRFTB) Tissue Access Committee.

October 19, 2026 GMT