Nexera Prep
Preparative Purification Liquid Chromatograph

Nexera Prep
The Nexera Prep systems are designed for fast and efficient purification of target compounds. It helps to streamline the purification process and purity check analysis. The Nexera Prep system is equipped with a simple user interface which allows easy setting of multiple fractionation parameters, analytical conditions, and reporting. Shimadzu offers preparative LC systems for all laboratory scales, from microgram-scale to gram-scale purification. This system also features Open Solution™ – a tailored software for open access systems that greatly simplifies complex workflows.
- Easy optimization of preparative parameters and scale up
Fractionation simulation for rapid setup of collection logic Column line-up for scale-up from analytical to preparative - Time- and energy-saving by automation of the purification workflow
Collection of target components at high purity by automated desalting - Expandable to suit the sample/fraction number and volume
Choose from a wide range of options for recovery scale and analytical detection Problems are resolved simply, to accommodate a variety of needs.
Streamline and Simplify Establishing the Conditions for Preparative Work
Using the Nexera Prep system saves on labor when scaling up from the development of analytical conditions to the conditions for preparative work.
Preparative Work for Target Components at High Purity Levels and High Concentrations
The Nexera UFPLC™, Ultra Fast Preparative and Purification Liquid Chromatograph, significantly reduces the cost and labor involved in preparative purification. Additionally, the system not only performs purification of target components, but can also recover impurities with high yield, enabling direct impurity analysis.
Streamline and Simplify Establishing the Conditions for Preparative Work
With LH-40 and FRC-40 able to perform signal-based logic and collection on up to four signal channels, not having a chromophore is not a limitation. Nexera Prep can use LCMS, RID, and ELSD to detect and/or identify targets for purification.
Increased Efficiency from Preparative Analysis Setup to Data Processing
Open Solution™ is open access software that not only streamlines preparative purification operations, but also supports multi-user operation of preparative systems.
Prep Solution is straightforward to operate even for inexperienced users, because the number of parameter settings characteristic of preparative work has been reduced to the utmost.
Increased Efficiency from Preparative Analysis Setup to Data Processing
By repeatedly cycling the sample through the column, the target component can be resolved and recovered from coeluting species or impurities without the need for longer or multiple columns.
Excellent System Expandability
The solvent delivery unit and fraction collector can be selected to suit the recovery volume. Sample introduction and reinjection options cover a wide range of uses. Additionally, the Shim-pack Scepter™ columns feature excellent scalability from analytical to preparative separations with a variety of phases for different applications.
Nexera, Open Solution, Shim-pack Scepter, LabSolutions and Purication Solution are trademarks of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.
Features
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Using the Nexera™ Prep system saves on labor when scaling up from the development of analytical conditions to the conditions for preparative work.
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The Shimadzu UFPLC, Ultra Fast Preparative and Purification Liquid Chromatograph significantly reduces the cost and labor involved in preparative purification. Additionally, the system not only performs purification of target components, but can also recover impurities with high yield enabling direct impurity analysis.
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With LH-40 and FRC-40 able to perform signal-based logic and collection on up to four signal channels, not having a chromophore is not a limitation. Nexera Prep can use LCMS, RID, and ELSD to detect and/or identify targets for purification.
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Open Solution is open access software that not only streamlines preparative purification operations, but also supports multi-user operation of preparative systems.
-
By repeatedly cycling the sample through the column, the target component can be resolved and recovered from coeluting species or impurities without the need for longer or multiple columns.
-
The solvent delivery unit and fraction collector can be selected to suit the recovery volume. Sample introduction and reinjection options cover a wide range of uses. Additionally, the Shim-pack™ Scepter columns feature excellent scalability from analytical to preparative separations with a variety of phases for different applications.
Latest Webinar
News / Events
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Shimadzu has released the Nexera X4 Ultra High Performance Liquid Chromatograph.
Expanding on technologies cultivated with previous Nexera series models, the next-generation Nexera X4 ultra high performance liquid chromatograph (UHPLC) achieves an incomparable level of analytical performance. The lowest degree of peak broadening* in the industry results in ultra-sharp peaks and outstanding separation performance while cutting-edge fluid control technology provides exceptional solvent delivery consistency, even for fast analysis under ultra-high-pressure conditions, and highly reliable results. Engineered with precision, the high-end Nexera X4 UHPLC offers new value for all laboratories that demand maximum performance.
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Nexera IC Ion Chromatograph has been released.
The Nexera IC ion chromatograph combines a compact footprint with uncompromising performance, enabling anyone to perform analysis effortlessly and efficiently.
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PL-40, Automation-Compatible Plate Loader for LC/LC-MS Systems has been released
The PL-40 solves for LC/LC-MS automation, it seamlessly loads plates of pretreated samples into an LC/LC-MS system, enabling a fully automated workflow, from pretreatment to analysis.
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New Technical Report is available, Optimization of Supercritical Fluid Extraction Parameters for Vitamins D2, D3, and K1 from Pharmaceutical Preparations
New Technical Report is available, Optimization of Supercritical Fluid Extraction Parameters for Vitamins D2, D3, and K1 from Pharmaceutical Preparations
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New Tips & Tricks is available, Automated Dilution and Preparation of Standard and Sample Solutions for Analysis
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Shimadzu Corporation has released LabSolutions Detect, a software with AI Functionality to support Anomaly Detection for Liquid Chromatographs (LC).
LabSolutions Detect transforms your LC data review process by visualizing differences between accumulated reference data and daily sample data.