Comprehensive 2D-LC is a analytical methodology combining two independent separation modes orthogonally, greatly increasing separation efficiency.
Nexera-e
Comprehensive Two-Dimensional Liquid Chromatograph
Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved.
The new Nexera-e is the ideal solution for the separation and characterization of most challenging and complex samples. It is particularly useful for the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.
Improved resolving power compared to conventional 1D-LC
How many peaks are co-eluted under one peak? The more complex the sample, along with a high percentage of similar compounds, there exists a high probability of co-eluting compounds found under single peaks.
Even though the co-eluting compounds may not be separated by mono-dimensional separation, an orthogonal two-dimensional system will provide the best possible result.
Comparison of chromatograms (traditional Chinese medicine)
Features
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Shimadzu triple quadrupole mass spectrometers (TQMS) have the world-class polarity reversal speed (5 ms) and data capture speed (1.5 ms). In comprehensive 2D-LC analysis, the analysis time of second dimension is short, therefore the high-speed performance of the LC-MS affects the quality of the data. -
Comprehensive 2D-LC often requires complicated software operation for setting 1D and 2D analytical conditions. LabSolutions provides an easy parameter setting and contributes to the simple operation.
News / Events
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Oligonucleotide Therapeutics Solution Guide is now available
Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases (including modified bases) linked together. They are produced by chemical synthesis and act directly on organisms without being translated into proteins.
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Cosmetics and Personal Care Products
The environment surrounding cosmetics and personal care products is changing. In addition to serving the original aesthetic purpose, cosmetics are required to be environmentally friendly and impart no adverse effects on animals.
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Shimadzu has released the Catechin Analysis Kit
The National Agriculture and Food Research Organization (NARO) and Shimadzu are studying fast, convenient, and accurate methods for analyzing the functional components in foods for purposes of data analysis and social implementation.
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Shimadzu has updated the LabSolutions MD
LabSolutions MD uses an “Analytical Quality by Design” (AQbD) approach for achieving efficient method development by designing analysis methods based on science and risk.
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Biodegradable Plastics
In order to reduce plastic waste, the development of eco-friendly alternative materials is being promoted. As an alternative, biomass plastics and biodegradable plastics are becoming more widely available. Biodegradable Plastics are plastics that are decomposed into low-molecular compounds by microorganisms in the environment. So they break down easily in nature, which is an opposite characteristic of petroleum-based plastics.
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Shimadzu has released the Nexera lite inert
Nexera lite inert is a robust HPLC system that eliminates the risk of corrosion by high-salt mobile phases and sample adsorption onto metal surfaces. It improves the data quality of protein analysis in biological samples with superior reproducibility, without any special considerations for stable and long-term use.