Supercritical fluid chromatography (SFC) is a separation method that uses supercritical carbon dioxide as the mobile phase. Though SFC technology has existed for a long time, but due to recent advancements in SFC instrument and column technologies, it is now beginning to be used for regular lab use and measurements. By using supercritical carbon dioxide, which can be mixed with water-soluble solvents despite its low polarity, SFC offers potential advanced separation methods that are different from conventional GC and HPLC separation. This chapter describes what is supercritical carbon dioxide with an overview about new separation methods which are made possible using supercritical carbon dioxide.

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