Nexera XR

Ultra High Performance Liquid Chromatograph

Detectors Featuring World-Leading Sensitivity

Photodiode Array Detectors

The lineup of photodiode array detectors consists of the SPD-M20A and SPD-M30A. Both models are temperature-controlled, heightening data reliability and baseline stability with respect to room temperature fluctuations. The SPD-M30A incorporates a new type of capillary cell to function as a higher-sensitivity and lower-dispersion system. The SPD-M20A is an easy-to-use model that covers a wide detection range.

85 mm Optical Path Length Significantly Enhances Sensitivity

The SPD-M30A high-sensitivity cell is also effective under HPLC conditions. The analysis below shows a comparison of measurements of caffeine in a commercial soft drink using the SPD-M20A and SPD-M30A. It is apparent that the SPD-M30A improves the S/N ratio by up to eleven times.

New Analytical Techniques to Better Utilize PDA Detector Data

This technique fully separates unseparated peaks and visualizes small peaks hidden by a principal component. It is convenient when poor separation occurs under conditions for accelerated analysis and for quantitation of small peaks overlapped by a principal component peak.

* i-PDeA: Intelligent Peak Deconvolution Analysis

This powerful technique permits quantitation of samples in the high-concentration range. It enables the simultaneous analysis of high- and ultra-low-concentration samples and the creation of calibration curves across a broad concentration range.

** i-DReC: Intelligent Dynamic Range Extension Calculator

Fluorescence Detectors

The RF-20A/20Axs fluorescence detectors offer world-leading* sensitivity and ease of maintenance. The high-sensitivity RF-20Axs model incorporates a temperature-controlled cell with cooling functionality. This maintains a constant detector cell temperature, even if the room temperature fluctuates significantly, to ensure superb reproducibility with no drop in sensitivity.

* As of August 2013, according to Shimadzu survey.

Ultra-High-Sensitivity Analysis of Anthracene (RF-20Axs)

An S/N ratio of 21.5 was achieved for an injection of 10.48 fg anthracene (RF-20Axs). This is equivalent to approx. 1.5 fg limit of detection (S/N ratio = 3), which is excellent.

Multi-Component, High-Sensitivity UFLC Analysis

The highly sensitive simultaneous analysis of multiple components requires detection at the optimal wavelengths. The RF-20A/20Axs permit ultra fast, high-sensitivity multi-component analysis using wavelength switching via a time program.

Support for Improved Quantitative Analysis Accuracy: Utility of Four-Wavelength Measurement Function

Support for Improved Quantitative Analysis Accuracy: Utility of Four-Wavelength Measurement Function

Using detection at a single wavelength when performing multicomponent simultaneous analysis of components with different optimal detection wavelengths necessitates sacrificing sensitivity for certain components.
The RF-20A/20Axs detectors eliminate this issue by incorporating a four-wavelength measurement function that permits detection of each component at the optimal wavelength.
Detection using wavelength switching in the left-hand diagram exhibits incomplete separation in area (1) and one peak of reduced size in area (2). In such a case, setting up to four optimal wavelengths enhances the quantitative analysis accuracy by reducing the effects of adjacent peaks and improving sensitivity.

Analysis of Polycyclic Aromatics by Four-Wavelength Simultaneous Measurement (Elution sequence shown in previous diagram)

For Research Use Only. Not for use in diagnostic procedures.

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