Nexera XS inert
Ultra High Performance Liquid Chromatograph
For many biopharmaceuticals and medium-molecule drugs, it can be difficult to acquire reliable data using a typical HPLC system, due to adsorption caused by interactions with metal ions. That tendency is particularly true for molecules that contain phosphates, carbonyl groups, or other characteristic elements or functional groups, the adsorption of which can affect analysis in various ways, such as by causing poor peak shape or inadequate sensitivity. Therefore, to increase the sensitivity and accuracy of analysis, it is important to inhibit the adsorption of compounds to the system.
In addition to the standard Nexera models made with stainless steel for excellent pressure resistance, broad applicability, and robustness, a new bioinert model has been added to the Nexera series product line. Nexera XS inert UHPLC systems achieve a 105 MPa pressure capacity while inhibiting adsorption to metals by using PEEK or ceramic materials in flow channels where samples flow. They also offer excellent resistance to corrosion and a broad range of pH levels, meaning they can be operated reliably using mobile phases that contain high haloid salt concentrations or have extreme pH levels.
Features
Videos
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Nexera XS inert
The potential adsorption of an analyte onto wetted surfaces of UHPLC instruments poses some critical challenges when analyzing biomolecules. While elevated pressure tolerance is required to achieve optimal chromatographic separation through the use columns with a small particle size, the inertness of the wetted surfaces is also of the utmost importance as is resistance to corrosion due to the use of mobile phases with high salt concentrations and extreme pH values. The Nexera XS inert system offers the ideal solution for the separation of molecules by combining the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, ensured by the absence of wetted metal surfaces and offering ultra-high resistance to corrosion.
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Nexera XS inert UHPLC: Clearly Higher Peaks for Bioanalysis
This video provides an overview and description of the Nexera XS inert UHPLC, which combines the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, making it ideal for the analysis of biomolecules that adsorb to metal surfaces in liquid chromatography systems. Watch the video to learn about the key components of this system.
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New Breakthrough in Biologics Analysis with Bioinert, Biocompatible and High-Pressure UHPLC
Modern biotherapeutics, such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and nucleic acid drugs provide new modalities to tackle persistent health concerns. To ensure patient safety and therapeutic quality, ICH-Q6B requires biological products to be tested for impurities and or separated during manufacturing process to determine the level of impurities present. Most of these analyses are performed using ultra-high performance liquid chromatography (UHPLC). Using small particles, acid, buffer solutions, organic solvents, and high salt concentrations in standard UHPLC systems can lead to corrosion, accelerated wear, and diminished performance. Analyzing biomolecules by UHPLC also poses some significant challenges due to the potential adsorption of analytes onto the wetted surfaces of the instrument, especially stainless steel materials like needles, tubing, and flow cells. The Nexera XS inert system offers a perfect solution for biopharmaceutical analytical method development, method scouting and quality control by incorporating the high-pressure tolerance of UHPLC alongside complete inertness of the sample flow path, which is achieved by eliminating wetted metal surfaces and offering an ultra-high corrosion resistance for SEC, IEX, and HIC chromatographic methods.
News / Events
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Shimadzu has released the Shim-pack Mix-HILIC, Chromatography Column for Hydrophilic Interactions
Comprehensive Analysis of Hydrophilic Metabolites in Metabolomics
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A new video has been released -Finding Out What Makes Things Sour-
Ever wondered what makes some foods sour? In this video we explore that question while also introducing one of Japan's traditional sour foods!
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New Nexera FV
Nexera FV and LabSolutions™ FV together form a new UHPLC system capable of monitoring flow synthesis and batch synthesis reactions, and automating formulation dissolution testing.
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Pharmaceutical and Biopharmaceutical has been updated.
Shimadzu Corporation has always been a reliable partner for the pharmaceutical industry. We provide comprehensive analytical solutions for all drug research analysis and productions and help companies to increase efficiency, reduce cost, and ensure drug safety and quality.
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On-line extraction and determination of targeted carotenoids from habanero red (Capsicum Chinese)
The on-line coupling between supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC), generate a powerful tool for the automatic extraction and detection of target compounds from food matrices. The on-line nature of the system, compared to off-line
approaches, improves run-to-run precision, enables the setting of batch-type applications, and reduces the risks of sample contamination. Supercritical carbon dioxide (CO2) presents unique characteristics, which make it an excellent solvent, it shows a relatively high density and
consequently, a high solvation power. -
New Nexera UC Prep
The Nexera™ UC Prep is a new preparative supercritical fluid chromatography (SFC) system that offers both the high basic performance developed for the previous Nexera UC model and original state-of-the-art preparative SFC technologies. It resolves a number of issues in preparative tasks, reducing labor and improving efficiency while fitting into pre-existing workflows.